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IN VITRO DATA

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Chemical Study No. Vehicle SpeciesSite Membrane Area (cm2)Cell TypeExposure Time (h)Length of Study(h)% Recovery% Penetrated% Absorbeds-s-flux (mcrg/cm2/h)kp (cm/h)nLag Time (h)Ref.No
Coumarin1509Phosphate Buffer (pH 7.4)HumanAbdomenFull Thickness Skin0.636Static4848   0.130.009151.61236
Coumarin1511Phosphate Buffer (pH 7.4)HumanScalpFull Thickness Skin0.636Static4848   0.1720.012550.36236
Griseofulvin1512Phosphate Buffer (pH 7.4)HumanAbdomenFull Thickness Skin0.636Static4848   0.01040.0013519.2236
Griseofulvin1513Phosphate Buffer (pH 7.4)HumanScalpFull Thickness Skin0.636Static4848   0.01550.00194516.9236
Propranolol1514Phosphate Buffer (pH 7.4)HumanAbdomenFull Thickness Skin0.636Static4848   0.03040.0012517.7236
Propranolol1515Phosphate Buffer (pH 7.4)HumanScalpFull Thickness Skin0.636Static4848   0.04250.0017511236
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