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IN VITRO DATA

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Chemical Study No. Vehicle SpeciesSite Membrane Area (cm2)Cell TypeExposure Time (h)Length of Study(h)% Recovery% Penetrated% Absorbeds-s-flux (mcrg/cm2/h)kp (cm/h)nLag Time (h)Ref.No
Etorphine1599HCl & isotonic TRIS bufferMouseAbdominal and DorsalFull Thickness Skin0.64Static2424    0.002963.6265
Etorphine1600HCl & isotonic TRIS bufferMouseAbdominal and DorsalFull Thickness Skin0.64Static2424    0.004652.9265
Etorphine1601HCl & isotonic TRIS bufferMouseAbdominal and DorsalFull Thickness Skin0.64Static2424    0.003563.7265
Etorphine1602HCl & isotonic TRIS bufferHumanAbdominalFull Thickness Skin0.64Static2424    0.003663.1265
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