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IN VITRO DATA

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Chemical Study No. Vehicle SpeciesSite Membrane Area (cm2)Cell TypeExposure Time (h)Length of Study(h)% Recovery% Penetrated% Absorbeds-s-flux (mcrg/cm2/h)kp (cm/h)nLag Time (h)Ref.No
Morphine1604physiological phosphate bufferHumanAbdomenIsolated Epidermis0.785Static5252   0.0069.3E-0645.2266
Codeine1605physiological phosphate bufferHumanAbdomenIsolated Epidermis0.785Static2424   0.094.9E-0547.6266
Hydromorphone1606physiological phosphate bufferHumanAbdomenIsolated Epidermis0.785Static5656   0.0321.5E-0549.9266
Meperidine1607physiological phosphate bufferHumanAbdomenIsolated Epidermis0.785Static88   0.60.003741.2266
Fentanyl1608physiological phosphate bufferHumanAbdomenIsolated Epidermis0.785Static99   0.260.005641.9266
Sufentanil1609physiological phosphate bufferHumanAbdomenIsolated Epidermis0.785Static8.58.5   0.40.01242266
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