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IN VITRO DATA
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Chemical Study No. Vehicle SpeciesSite Membrane Area (cm2)Cell TypeExposure Time (h)Length of Study(h)% Recovery% Penetrated% Absorbeds-s-flux (mcrg/cm2/h)kp (cm/h)nLag Time (h)Ref.No
Captopril376WaterRabbitAbdomenFull Thickness Skin2Static4848   5.4 32.1761
Captopril377Water & 5% Benzalkonium ChlorideRabbitAbdomenFull Thickness Skin2Static4848   157.64 35.6161
Captopril378Water & 5% Cetylpyridinium chlorideRabbitAbdomenFull Thickness Skin2Static4848   200.35 36.1861
Captopril379Water & 5% Sodium Lauryl SulphateRabbitAbdomenFull Thickness Skin2Static4848   313.96 35.1861
Captopril380Water & 5% Tween 20RabbitAbdomenFull Thickness Skin2Static4848   221.46 36.0461
Captopril381Water & 5% Tween 40RabbitAbdomenFull Thickness Skin2Static4848   34.78 35.9661
Captopril382Water & 5% Tween 60RabbitAbdomenFull Thickness Skin2Static4848   27.56 36.4761
Captopril383Water & 5% Tween 80RabbitAbdomenFull Thickness Skin2Static4848   83.81 36.1361
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