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IN VITRO DATA

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Chemical Study No. Vehicle SpeciesSite Membrane Area (cm2)Cell TypeExposure Time (h)Length of Study(h)% Recovery% Penetrated% Absorbeds-s-flux (mcrg/cm2/h)kp (cm/h)nLag Time (h)Ref.No
Dimethylnitrosamine1040Isopropyl myristate + Sucrose(3H)HumanAbdomenIsolated Epidermis1Static48488.393.352.57  8 135
n-Nitrosodiethanolamine1041Isopropyl myristate + Sucrose(3H)HumanAbdomenIsolated Epidermis1Static4848109.9469.4723.594.10.004185.4135
Dimethylnitrosamine1042oil-in-water (see notes) + Sucrose(3H)HumanAbdomenIsolated Epidermis1Static48487.275.183.98  12 135
Dimethylnitrosamine1043shampoo + Sucrose(3H)HumanAbdomenIsolated Epidermis1Static484873.041.181.1  12 135
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