DATA BY REFERENCE
Type a Reference Number into the Text Box or Select one from the List and then press Submit:
Reference Number:
All References
1
2
3
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
121
124
128
130
131
133
135
136
138
140
141
142
145
148
149
151
153
155
156
158
159
160
162
165
166
167
168
169
170
171
174
175
177
178
179
181
182
184
185
187
188
189
192
194
196
197
199
200
201
202
203
204
205
206
207
211
212
213
214
215
216
217
218
219
220
221
224
226
227
228
231
232
234
236
238
240
242
243
245
246
248
251
253
254
257
258
259
260
262
264
265
266
269
271
273
276
281
282
285
286
288
290
292
295
296
297
298
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
331
333
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
IN VITRO DATA
Page 1 of 1.
5
records found
Click the Study No. for further experimental detail
Chemical
Study No.
Vehicle
Species
Site
Membrane
Area (cm2)
Cell Type
Exposure Time (h)
Length of Study(h)
% Recovery
% Penetrated
% Absorbed
s-s-flux (mcrg/cm2/h)
kp (cm/h)
n
Lag Time (h)
Ref.No
Benzo[a]pyrene
1067
Acetone
Rat
Back
Dermatomed to 0.5mm
0.64
Flow-through
24
48
101.7
74
51.1
4
151
Benzo[a]pyrene
1068
Acetone
Guinea pig
Back
Dermatomed to 0.5mm
0.64
Flow-through
24
48
99.2
45.7
27.5
4
151
Benzo[a]pyrene
1069
Acetone
Human
Abdomen
Dermatomed to 0.5mm
0.64
Flow-through
24
48
100.5
9.9
3.3
4
151
Benzo[a]pyrene
1070
Acetone
Human
Abdomen
Dermatomed to 0.5mm
0.64
Flow-through
24
48
102.1
8.8
1.5
4
151
Benzo[a]pyrene
1071
Acetone
Testskin TM
cultured human foreskin
Full Thickness Skin (0.3mm)
0.64
Flow-through
24
48
97.4
0.8
0.2
4
151
Previous
Next
IN VIVO DATA
Page 1 of 1
2
records found
Click the Study No. for further experimental detail
Chemical
Study No.
Vehicle
Species
Site
Dose (ml)
Area (cm2)
Concentration mg/ml
Exposure Time (h)
Length of Study (h)
% Absorbed
Maximal Flux (mcrg/cm2/h)
n
kp (cm/h)
Lag Time (h)
Reference Number
Benzo[a]pyrene
563
Acetone
Guinea pig
mid-dorsal
0.05
4.2
0.764
24
336
67.8
4
151
Benzo[a]pyrene
564
Acetone
Rat
mid-dorsal
0.05
4.2
0.512
24
336
67.8
4
151
Previous
Next
