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IN VITRO DATA

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Chemical Study No. Vehicle SpeciesSite Membrane Area (cm2)Cell TypeExposure Time (h)Length of Study(h)% Recovery% Penetrated% Absorbeds-s-flux (mcrg/cm2/h)kp (cm/h)nLag Time (h)Ref.No
Hydrocortisone73WaterTestskin TMN/A3microm pore size polycarbonate membrane0.5Static2424    0.00263 17
Caffeine74WaterTestskin TMN/A3microm pore size polycarbonate membrane0.5Static2424    0.023 17
Caffeine75WaterTestskin TMN/A3microm pore size polycarbonate membrane0.5Static2424    0.0113 17
Caffeine76PetrolatumTestskin TMN/A3microm pore size polycarbonate membrane0.8Static2424    0.00243 17
Caffeine77PetrolatumTestskin TMN/A3microm pore size polycarbonate membrane0.8Static2424    0.00113 17
Benzoic Acid78WaterTestskin TMN/A3microm pore size polycarbonate membrane0.5Static2424    0.0863 17
Benzoic Acid79WaterTestskin TMN/A3microm pore size polycarbonate membrane0.5Static2424    0.00863 17
Benzoic Acid80PetrolatumTestskin TMN/A3microm pore size polycarbonate membrane0.8Static2424    0.00673 17
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