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IN VITRO DATA

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Chemical Study No. Vehicle SpeciesSite Membrane Area (cm2)Cell TypeExposure Time (h)Length of Study(h)% Recovery% Penetrated% Absorbeds-s-flux (mcrg/cm2/h)kp (cm/h)nLag Time (h)Ref.No
Hydrocortisone1227SalineMouseAbdomenFull Thickness Skin0.6Static4040    0.000137.6185
Hydrocortisone1228SalineMouseDorsalFull Thickness Skin0.6Static4040    0.0001239.9185
Hydrocortisone1229SalineMouseAbdomenFull Thickness Skin0.6Static4040    0.0003734.4185
Hydrocortisone1230SalineMouseDorsalFull Thickness Skin0.6Static4040    0.0004537.8185
Hydrocortisone1231SalineMouseAbdomenFull Thickness Skin0.6Static4040    0.0003435.3185
Hydrocortisone1232SalineMouseDorsalFull Thickness Skin0.6Static4040    0.0004436.2185
Hydrocortisone1233SalineMouseAbdomenFull Thickness Skin0.6Static4040    0.0003135.9185
Hydrocortisone1234SalineMouseDorsalFull Thickness Skin0.6Static4040    0.0003137.4185
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