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IN VITRO DATA

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Chemical Study No. Vehicle SpeciesSite Membrane Area (cm2)Cell TypeExposure Time (h)Length of Study(h)% Recovery% Penetrated% Absorbeds-s-flux (mcrg/cm2/h)kp (cm/h)nLag Time (h)Ref.No
Theophylline1245PEG 400RatDorsalDermatomed to 0.45mm0.64Flow-through2424   1.98 9 200
Theophylline1246GlycerinRatDorsalDermatomed to 0.45mm0.64Flow-through2424   2.52 5 200
Theophylline1247DMISRatDorsalDermatomed to 0.45mm0.64Flow-through2424   5.23 6 200
Theophylline1248Propylene glycolRatDorsalDermatomed to 0.45mm0.64Flow-through2424   7.93 6 200
Theophylline12491-propanolRatDorsalDermatomed to 0.45mm0.64Flow-through2424   37.84 6 200
Theophylline1250EthanolRatDorsalDermatomed to 0.45mm0.64Flow-through2424   52.25 6 200
Theophylline1251MethanolRatDorsalDermatomed to 0.45mm0.64Flow-through2424   117.11 6 200
Theophylline1252WaterRatDorsalDermatomed to 0.45mm0.64Flow-through2424   21.62 6 200
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