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Chemical Study No. Vehicle SpeciesSite Membrane Area (cm2)Cell TypeExposure Time (h)Length of Study(h)% Recovery% Penetrated% Absorbeds-s-flux (mcrg/cm2/h)kp (cm/h)nLag Time (h)Ref.No
Caffeine1450Vaseline Intensive CareHumanAbdomenDermatomed to 0.35mm0.32Flow-through2472  40.6  4 224
Benzoic Acid1451Vaseline Intensive CareHumanAbdomenDermatomed to 0.35mm0.32Flow-through2472  27.5  3 224
Cortisone1452Vaseline Intensive CareHumanAbdomenDermatomed to 0.35mm0.32Flow-through2472  6.7  7 224
Nicotinic Acid1453Vaseline Intensive CareHumanAbdomenDermatomed to 0.35mm0.32Flow-through2472  2.1  7 224
Phenol1454Vaseline Intensive CareHumanAbdomenDermatomed to 0.35mm0.32Flow-through2472  25.5  7 224
Propylene glycol1455Vaseline Intensive CareHumanAbdomenDermatomed to 0.35mm0.32Flow-through2472  13.8  6 224
Urea1456Vaseline Intensive CareHumanAbdomenDermatomed to 0.35mm0.32Flow-through2472  9.5  4 224
Caffeine1457Vaseline Intensive CareRatBackDermatomed to 0.35mm0.32Flow-through2472  56.3  5 224
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Chemical Study No. VehicleSpeciesSiteDose (ml)Area (cm2)Concentration mg/mlExposure Time (h)Length of Study (h)% AbsorbedMaximal Flux (mcrg/cm2/h)nkp (cm/h)Lag Time (h)Reference Number
Cortisone809PetrolatumRatBack 1.25 24 19.9 4  224
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