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IN VITRO DATA
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Chemical Study No. Vehicle SpeciesSite Membrane Area (cm2)Cell TypeExposure Time (h)Length of Study(h)% Recovery% Penetrated% Absorbeds-s-flux (mcrg/cm2/h)kp (cm/h)nLag Time (h)Ref.No
Butyl 4-hydroxybenzoate1517WaterGuinea pigDorsalFull Thickness Skin3.14Flow-through2424  23.7 0.007082  238
Butyl 4-hydroxybenzoate1518aq. propylene GlycolGuinea pigDorsalFull Thickness Skin3.14Flow-through2424  20.22 0.00537  238
Butyl 4-hydroxybenzoate1519aq. Polyethylene glycol 400Guinea pigDorsalFull Thickness Skin3.14Flow-through2424  5.7 0.001676  238
Butyl 4-hydroxybenzoate1520aq. Propylene glycolGuinea pigDorsalFull Thickness Skin3.14Flow-through2424  9.54 0.002688  238
Butyl 4-hydroxybenzoate1521 aq. Polyethylene glycol 400Guinea pigDorsalFull Thickness Skin3.14Flow-through2424  1.95 0.000752  238
Butyl 4-hydroxybenzoate1522aq. Polysorbate 80Guinea pigDorsalFull Thickness Skin3.14Flow-through2424  3.64 0.00936  238
Butyl 4-hydroxybenzoate1523aq. Polysorbate 80 & propylene glycolGuinea pigDorsalFull Thickness Skin3.14Flow-through2424  3.54 0.001204  238
Butyl 4-hydroxybenzoate1524aq. Polysorbate 80 & polyethylene glycol 400Guinea pigDorsalFull Thickness Skin3.14Flow-through2424  2.17 0.000708  238
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