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IN VITRO DATA

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Chemical Study No. Vehicle SpeciesSite Membrane Area (cm2)Cell TypeExposure Time (h)Length of Study(h)% Recovery% Penetrated% Absorbeds-s-flux (mcrg/cm2/h)kp (cm/h)nLag Time (h)Ref.No
Caffeine166050% aq. EthanolHumanBreastFull Thickness Skin0.64Flow-through2424 25.817.11.8 51.6290
Caffeine166150% aq. EthanolRatNot GivenFull Thickness Skin0.64Flow-through2424 70.125.84.1 50.7290
Caffeine166250% aq. EthanolHumanBreastDermatomed to 0.28mm0.64Flow-through2424 21.8183.8 50.9290
Caffeine166350% aq. EthanolHumanBreastFull Thickness Skin0.64Flow-through2424 32.320.30.9 51.6290
Caffeine166450% aq. EthanolHumanBreastFull Thickness Skin0.64Flow-through2424 2215.718 51.6290
Caffeine166550% aq. EthanolHumanBreastFull Thickness Skin0.64Flow-through2424 106.218.2 52290
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