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IN VITRO DATA
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Chemical Study No. Vehicle SpeciesSite Membrane Area (cm2)Cell TypeExposure Time (h)Length of Study(h)% Recovery% Penetrated% Absorbeds-s-flux (mcrg/cm2/h)kp (cm/h)nLag Time (h)Ref.No
Dinitrochlorobenzene264AcetoneMouseDorsalFull Thickness Skin0.64Flow-through2424115.781.273  36 51
Dinitrochlorobenzene265AcetoneMouseDorsalFull Thickness Skin0.64Flow-through242491.654.437.2  36 51
Dinitrochlorobenzene266AcetoneMouseDorsalFull Thickness Skin0.64Flow-through242489.361.610.5  36 51
Dinitrochlorobenzene267AcetoneRatDorsalFull Thickness Skin0.64Flow-through242448.832.419.6  6 51
Dinitrochlorobenzene268AcetoneRatDorsalFull Thickness Skin0.64Flow-through242476.829.413.4  6 51
Dinitrochlorobenzene269AcetoneRatDorsalFull Thickness Skin0.64Flow-through242476.758.844  6 51
Dinitrochlorobenzene270AcetoneRatDorsalFull Thickness Skin0.64Flow-through242472.465.742.7  6 51
Dinitrochlorobenzene271AcetoneRatDorsalDermatomed to 0.35mm0.64Flow-through242452.937.229.6  6 51
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