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IN VITRO DATA

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Chemical Study No. Vehicle SpeciesSite Membrane Area (cm2)Cell TypeExposure Time (h)Length of Study(h)% Recovery% Penetrated% Absorbeds-s-flux (mcrg/cm2/h)kp (cm/h)nLag Time (h)Ref.No
Methyl nicotinate804TranscutolRatAbdomenFull Thickness Skin2.54Static 0   28200.0032551.2599
Methyl nicotinate805Transcutol, Labrafac Hydrophile & DPPGRatAbdomenFull Thickness Skin2.54Static 0   22800.0027851.6799
Methyl nicotinate806Labrafac HydrophileRatAbdomenFull Thickness Skin2.54Static 0   16100.0022251.2599
Methyl nicotinate807Propylene glycol dipelargonateRatAbdomenFull Thickness Skin2.54Static 0   35600.0066350.7899
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