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IN VITRO DATA

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Chemical Study No. Vehicle SpeciesSite Membrane Area (cm2)Cell TypeExposure Time (h)Length of Study(h)% Recovery% Penetrated% Absorbeds-s-flux (mcrg/cm2/h)kp (cm/h)nLag Time (h)Ref.No
Testosterone67WaterTestskin TMN/A3microm pore size polycarbonate membrane0.5Static66   0.13920.02912 16
Testosterone68WaterTestskin TMN/A3microm pore size polycarbonate membrane0.5Static66   0.06720.01412 16
Testosterone69PetrolatumTestskin TMN/A3microm pore size polycarbonate membrane0.8Static66    0.000712 16
Testosterone70PetrolatumTestskin TMN/A3microm pore size polycarbonate membrane0.8Static66    0.001612 16
Beta-Estradiol71WaterTestskin TMN/A3microm pore size polycarbonate membrane0.5Static66    0.01912 16
Hydrocortisone72WaterTestskin TMN/A3microm pore size polycarbonate membrane0.5Static66    0.0005612 16
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