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IN VITRO DATA

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Chemical Study No. Vehicle SpeciesSite Membrane Area (cm2)Cell TypeExposure Time (h)Length of Study(h)% Recovery% Penetrated% Absorbeds-s-flux (mcrg/cm2/h)kp (cm/h)nLag Time (h)Ref.No
Lidocaine110340% propylene glycol & HCl (pH4)MouseDorsal/VentralFull Thickness Skin0.64Flow-through     589 33.64166
Lidocaine110440% propylene glycol & HCl (pH6)MouseDorsal/VentralFull Thickness Skin0.64Flow-through     878 30.77166
Lidocaine110540% propylene glycol & NaOH (pH7.8)MouseDorsal/VentralFull Thickness Skin0.64Flow-through     616 31.03166
Lidocaine110640% propylene glycol & NaOH (pH10)MouseDorsal/VentralFull Thickness Skin0.64Flow-through     511 30.74166
Lidocaine110740% propylene glycol & HCl (pH4)HumanLegDermatomed to 0.15mm0.64Flow-through     22.7 31.31166
Lidocaine110840% propylene glycol & HCl (pH6)HumanLegDermatomed to 0.15mm0.64Flow-through     19.4 30.69166
Lidocaine110940% propylene glycol & NaOH (pH7.8)HumanLegDermatomed to 0.15mm0.64Flow-through     238 30.96166
Lidocaine111040% propylene glycol & NaOH (pH10)HumanLegDermatomed to 0.15mm0.64Flow-through     208 30.89166
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