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IN VITRO DATA

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Chemical Study No. Vehicle SpeciesSite Membrane Area (cm2)Cell TypeExposure Time (h)Length of Study(h)% Recovery% Penetrated% Absorbeds-s-flux (mcrg/cm2/h)kp (cm/h)nLag Time (h)Ref.No
Testosterone105AcetoneMouseNot GivenFull Thickness Skin2Flow-through161694.13 65.13  5 24
Hydrocortisone106AcetoneMouseNot GivenFull Thickness Skin2Flow-through161695.68 18.1  20 24
Beta-Estradiol107AcetoneMouseNot GivenFull Thickness Skin2Flow-through161692.98 18  13 24
Estrone108AcetoneMouseNot GivenFull Thickness Skin2Flow-through161691.85 10.58  13 24
Estriol109AcetoneMouseNot GivenFull Thickness Skin2flow-through161688.66 2.35  14 24
Testosterone139AcetoneMouseNot GivenFull Thickness Skin2Flow-through1616  70.5    24
Testosterone140AcetoneMouseNot GivenFull Thickness Skin2Flow-through1616  44    24
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