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IN VITRO DATA
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Chemical Study No. Vehicle SpeciesSite Membrane Area (cm2)Cell TypeExposure Time (h)Length of Study(h)% Recovery% Penetrated% Absorbeds-s-flux (mcrg/cm2/h)kp (cm/h)nLag Time (h)Ref.No
Mannitol574Distilled WaterRatDorsalFull Thickness Skin2.54Static      0.00057923 71
Mannitol575Distilled WaterRatDorsalIsolated Epidermis2.54Static      0.000874 71
Mannitol576Distilled WaterRatDorsalIsolated Epidermis0.64Flow-through      0.0009056 71
Mannitol577Distilled WaterRatDorsalDermatomed to 0.23mm2.54Static      0.00039915 71
Mannitol578Distilled WaterRatDorsalDermatomed to 0.23mm0.64Flow-through      0.00087210 71
Mannitol579Distilled WaterPigOuter EarFull Thickness Skin2.54Static      0.00063626 71
Mannitol580Distilled WaterPigOuter EarIsolated Epidermis2.54Static      0.00023443 71
Mannitol581Distilled WaterPigOuter EarIsolated Epidermis0.64Flow-through      0.0015213 71
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