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IN VITRO DATA
Page 1 of 1.
7
records found
Click the Study No. for further experimental detail
Chemical
Study No.
Vehicle
Species
Site
Membrane
Area (cm2)
Cell Type
Exposure Time (h)
Length of Study(h)
% Recovery
% Penetrated
% Absorbed
s-s-flux (mcrg/cm2/h)
kp (cm/h)
n
Lag Time (h)
Ref.No
Coumarin
670
Ethanol
Human
Breast
Full Thickness Skin
0.32
Flow-through
72
72
74.6
60.2
50.4
0.0752
9
1.1
77
Coumarin
671
Ethanol
Rat
Dorsal
Full Thickness Skin
0.32
Flow-through
72
72
77.7
64
51.3
0.157
12
0.2
77
Coumarin
672
Ethanol
Mouse
Dorsal
Full Thickness Skin
0.32
Flow-through
72
72
83.9
76.6
44.9
0.1996
18
0.2
77
Coumarin
673
Ethanol
Human
Breast
Full Thickness Skin
0.32
Flow-through
72
72
85.2
74.5
66
0.1438
9
0.8
77
Coumarin
674
Ethanol
Rat
Dorsal
Full Thickness Skin
0.32
Flow-through
72
72
79.7
72.3
60.4
0.1517
12
0.2
77
Coumarin
675
Ethanol
Mouse
Dorsal
Full Thickness Skin
0.32
Flow-through
72
72
90.5
85.4
75
0.3447
18
0.2
77
Coumarin
676
Ethanol
Mouse
Dorsal
Full Thickness Skin
0.32
Flow-through
72
72
64.1
18
77
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IN VIVO DATA
Page 1 of 1
2
records found
Click the Study No. for further experimental detail
Chemical
Study No.
Vehicle
Species
Site
Dose (ml)
Area (cm2)
Concentration mg/ml
Exposure Time (h)
Length of Study (h)
% Absorbed
Maximal Flux (mcrg/cm2/h)
n
kp (cm/h)
Lag Time (h)
Reference Number
Coumarin
260
70& aq. Ethanol
Human
Back
1
100
2
6
120
59.7
3
77
Coumarin
261
70% aq. Ethanol
Rat
Back
0.2
9
0.9
6
120
69.3
2
77
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