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IN VITRO DATA
Page 1 of 1.
5
records found
Click the Study No. for further experimental detail
Chemical
Study No.
Vehicle
Species
Site
Membrane
Area (cm2)
Cell Type
Exposure Time (h)
Length of Study(h)
% Recovery
% Penetrated
% Absorbed
s-s-flux (mcrg/cm2/h)
kp (cm/h)
n
Lag Time (h)
Ref.No
n-Methyl-2-pyrrolidone
1667
None (Neat)
Rat
Back
Full Thickness Skin
1.76
Static
24
24
88.1
78.6
74.3
6
292
n-Methyl-2-pyrrolidone
1668
None (Neat)
Rat
Back
Full Thickness Skin
1.76
Static
24
24
86.6
75.8
69.8
6
292
n-Methyl-2-pyrrolidone
1669
None (Neat)
Rat
Back
Full Thickness Skin
1.76
Static
24
24
88.8
51.1
6
292
n-Methyl-2-pyrrolidone
1670
None (Neat)
Rat
Back
Full Thickness Skin
1.76
Static
24
24
84.2
51.7
33
7
292
n-Methyl-2-pyrrolidone
1671
None (Neat)
Rat
Back
Full Thickness Skin
1.76
Static
24
24
89.5
42.5
14.4
16
292
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IN VIVO DATA
Page 1 of 1
5
records found
Click the Study No. for further experimental detail
Chemical
Study No.
Vehicle
Species
Site
Dose (ml)
Area (cm2)
Concentration mg/ml
Exposure Time (h)
Length of Study (h)
% Absorbed
Maximal Flux (mcrg/cm2/h)
n
kp (cm/h)
Lag Time (h)
Reference Number
n-Methyl-2-pyrrolidone
844
None (Neat)
Rat
back
0.2
10
1033
0.5
0.5
18.03
4
292
n-Methyl-2-pyrrolidone
845
None (Neat)
Rat
back
0.2
10
1033
0.75
0.75
28.65
4
292
n-Methyl-2-pyrrolidone
846
None (Neat)
Rat
back
0.2
10
1033
1
1
36.44
4
292
n-Methyl-2-pyrrolidone
847
None (Neat)
Rat
back
0.2
10
1033
2
2
60.23
4
292
n-Methyl-2-pyrrolidone
843
None (Neat)
Rat
back
0.2
10
1033
0.25
0.25
6
4
292
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Next
