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IN VITRO DATA
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Chemical Study No. Vehicle SpeciesSite Membrane Area (cm2)Cell TypeExposure Time (h)Length of Study(h)% Recovery% Penetrated% Absorbeds-s-flux (mcrg/cm2/h)kp (cm/h)nLag Time (h)Ref.No
Mannitol203Distilled waterRatDorsalFull Thickness Skin2.54Static9696   0.3230.000323178 42
Mannitol204Distilled waterRatDorsalFull Thickness Skin2.54Static9696   0.2890.000289150 42
Mannitol205Distilled waterRatDorsalIsolated Epidermis2.54Static9696   0.230.0002330 42
Mannitol206Distilled waterRatDorsalIsolated Epidermis2.54Static9696   0.0898.9E-0522 42
Water2070.9% Physiological SalineRatDorsalFull Thickness Skin2.54Static9696    0.00143178 42
Water2080.9% Physiological SalineRatDorsalFull Thickness Skin2.54Static9696    0.00153150 42
Water2090.9% Physiological SalineRatDorsalIsolated Epidermis2.54Static9696    0.0011630 42
Water2100.9% Physiological SalineRatDorsalIsolated Epidermis2.54Static9696    0.0014122 42
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